Alzheimer’s disease works differently in patients with and without Down syndrome

first_imgLinkedIn Share Share on Twitter Researchers at the University of Kentucky’s Sanders-Brown Center on Aging have completed a study that revealed differences in the way brain inflammation — considered a key component of AD– is expressed in different subsets of patients, in particular people with Down syndrome (DS) and AD.People with Down syndrome have a third copy of Chromosome 21, and that chromosome is the same one responsible for the production of a molecule called amyloid precursor protein. Amyloid overproduction can lead to brain plaques that are a cardinal feature of Alzheimer’s, so it is not surprising that nearly 100 percent of people with Down syndrome develop Alzheimer’s disease pathology in their brain by the time they are 40.“People develop Alzheimer’s disease at different ages, but it’s typically in their 60s, 70s, or 80s,” said Donna Wilcock, an assistant professor at the Sanders-Brown Center on Aging and principal investigator for the study. “It’s a little easier to study Alzheimer’s disease in Down syndrome because of the predictability of the age when adults with DS develop signs of the disease.” Share on Facebookcenter_img Email Pinterest In Wilcock’s study, some interesting data emerged that will shape the way scientists look at AD as manifested in various subsets of the population. Using brain autopsy tissue from a group of people — some with DS/AD, some with AD alone, and some healthy, Wilcock and her team were able to determine differences in the way neuroinflammation was expressed in people with DS.In previous studies where Wilcock and her colleagues identified different types of inflammation in AD brains,, two families of inflammatory markers — called M1 and M2a — were each present to varying degrees in the sample population representing early AD cases, indicating a notable level of heterogeneity in the way the AD disease process begins in the brain. But in the late-stage AD cases, there was a high degree of homogeneity with high levels of the markers M1, M2 and M2c.“If you think of it in terms of a roadmap, there is almost always more than one way to get from Point A to Point B, and that seems to be the case in disease progression as well,” said Wilcock.In this most recent study, the team found that the inflammatory response in DS/AD brain tissue was significantly greater than that in tissue from AD patients. Further, there was an elevated level of markers for M2b,that was not replicated in tissue from sporadic (i.e. ideopathic) AD cases.. In other words, AD in the DS brain had a very different neuroinflammatory profile than AD in people without DS.“It has been generally assumed that AD presents the same way in people with Down syndrome as it does in people without DS, but our work demonstrates that this is not the case,” said Wilcock. “This will have important implications for the study of AD treatments, as some treatments might be effective with people without DS but not those with DS, and vice-versa.”Wilcock’s work has been published online in the Neurobiology of Aging. This study was part of a larger DS Aging study at the Sanders-Brown Center on Aging funded by NIH/NICHD (Head and Schmitt), and was also funded by a research grant awarded to Dr. Wilcock through a partnership between the Alzheimer’s Association, the Global Down Syndrome Foundation and the Linda CRNIC Institute for Down syndrome.last_img read more

Infants have social capacity to recognize new communicative signals in their environment

first_img“We reasoned that if infants were able to learn about a new communicative signal, they might now succeed in object categorizing while listening to tones, despite having failed in prior studies while listening to tones without any prior exposure to them,” said Brock Ferguson, lead author of the study and a doctoral candidate in cognitive psychology in the Weinberg College of Arts and Sciences at Northwestern. “That is, they might treat this new ‘communicative’ sound as if it were speech.”In contrast, Ferguson said, if infants couldn’t interpret this new signal as communicative, or if their categorization in the subsequent task could only be ‘boosted’ by speech, then infants should fail to categorize objects while listening to tones as they had in all prior studies.“We knew that speech could promote infants’ learning of object categories. Now we know that for infants, this link to learning is broad enough to encompass many communicative signals — including ones to which infants had just been introduced,” Ferguson said.Sandra Waxman, senior author of the study, director of the Project on Child Development, faculty fellow in Northwestern’s Institute for Policy Research and the Louis W. Menk Chair in Psychology at Northwestern, highlighted the powerful implications of this work for the understanding of infants’ intricate coordination of social, language and cognitive development.“Infants’ success in accepting this entirely novel signal as communicative is astounding,” Waxman said.“This shows that infants have the social capacity to recognize an entirely new social communicative signal in their environment. And once recognized, they can use it to support cognition. Babies, like adults, are already on the lookout for new ways that the people around them communicate with one another,” Waxman said.“What the [beep]? Six-month-olds link novel communicative signals to meaning” will be published in an upcoming issue of Cognition. Researchers have long known that adults can flexibly find new ways to communicate, for example, using smoke signals or Morse code to communicate at a distance, but a new Northwestern University study is the first to show that this same communicative flexibility is evident even in 6-month-olds.The researchers set out to discover whether infants could learn that a novel sound was a “communicative signal” and, if so, whether it would confer the same advantages for their learning as does speech.To do so, they had infants watch a short video in which two people had a conversation — one speaking in English and the other responding in beep sounds. Infants were then tested on whether these novel beep sounds would facilitate their learning about a novel object category, a fundamental cognitive process known to be influenced by speech. Could the beeps, once communicative, have the same effect? Indeed, the researchers found that after seeing the beeps used to communicate, the infants linked beep sounds to categorization just as if they were speech. Email Pinterest Sharecenter_img Share on Facebook Share on Twitter LinkedInlast_img read more

Elberon to Deal Replenishment Contract Awarded

first_imgCongressman Frank Pallone, Jr. said today that the federally funded contract for beach replenishment from Elberon to northern Deal has been awarded.  It will complete the second and final phase of the beach replenishment from Elberon and Loch Arbour.The project will cover the area stretching from Lake Takanassee in Elberon to Philips Avenue in Deal.The Army Corps of Engineers awarded the contract for the $86,722,210 project to Manson Construction Company.Work to replenish this stretch of the shore will begin this fall and will continue into 2016. The funding for this project is part of the Sandy aid package that Congressman Pallone fought for in Congress.“After a hard fight in Congress for the Sandy relief funding New Jersey deserves, I am glad to see this important beach replenishment project poised for completion,” said Congressman Pallone. “Beaches are a fundamental part of life for residents and the tourist economy, and they must be protected and maintained.”This contract will cover the placement of 3 million cubic yards of sand for reconstruction of the shoreline. It also includes lengthening 10 existing stormwater outfalls, and notching a groin at Phillips Avenue.[mappress mapid=”21111″]last_img read more

Construction Act: Pay up or else

first_imgStay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters Subscribe now for unlimited access To continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Get your free guest access  SIGN UP TODAY Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our communitylast_img read more

Linklaters adds to healthy magic circle retention rates

first_imgMagic circle firm Linklaters, the latest City outfit to reveal its autumn retention rate, is to retain 84% of its trainee cohort.The Silk Street-based firm said today it is taking on 47 of its 56-strong group of trainees.Excluding resignations, the firm made offers to 95% of the cohort. Six trainees decided not to accept. The figures are down on last year, however, when the firm offered jobs to all 56 trainees. The retention rate then was 91%, following five resignations.As the Gazette reported last week, Slaughter and May leads the way in the magic circle so far, taking on 29 of 32 trainees.Allen & Overy had 47 trainees on its programme, all of whom applied. The firm made offers to 41 and 40 accepted, giving it an 85% retention rate.The outlier is Freshfields Bruckhaus Deringer, which recorded a sharp dip on last year.The magic circle firm offered contracts to 29 of 41 trainees this time, with 27 accepting a role (66%).last_img read more

Buckland rules out judge-only trials as solution to virus backlog

first_imgThe lord chancellor says judge-only Crown court trials would be a ‘disproportionate step’ to keep the justice system moving during the pandemic, as he revealed today that he is looking at ways to bring back jury trials.Robert Buckland QC, giving evidence to the Joint Committee on Human Rights on the government’s Covid-19 response, was asked by the SNP’s Joanna Cherry QC about jury trials, which have been paused in England and Wales.Cherry pointed out that Scotland is currently looking at how to hold jury trials during the pandemic. Proposals being explored include juries of fewer members as happened in World War Two, social distancing measures using the public gallery in the court, and empanelling juries remotely.Buckland began his response by welcoming the Scottish government’s ‘change of heart’ over judge-only courts. He said judge-only courts were a disproportionate step which would have wider consequences ‘we would all regret’.Buckland, a criminal barrister, said he was a great believer in the jury system and will do everything he can to preserve it. The concept of what happened in World War Two ‘is one that is worth serious consideration’, he said. Legal thinktank Justice’s work on remote jury trials ‘merits careful scrutiny’.He was ‘deeply encouraged’ by the work being done by colleagues at the bar in court centres like Cardiff ‘where everyone is getting involved in literally measuring out how court centres like Cardiff can operate jury trials safely’.He said: ‘The key thing for me is seeing how quickly we can get jury trials back up and running. The most sure-fire way of doing that is by making sure we have space within the court system to do that. If it means at Cardiff Crown Court, they are able to run a couple of courts in the main building, perhaps a few more jury trial courts in another public building nearby, that would be a real contribution to getting at least some of the shorter, more straightforward jury trials moving once again.’Buckland told the committee he was impressed at how courts have rationalised operations. ‘Things that would have been scarce believable only two months ago are now being achieved by way of technology.’The committee was told the judiciary is planning for what the recovery might look like in terms of how the courts can operate once the immediate lockdown eases and to scale up operations to clear the backlog.Buckland does not want a return to the status quo. He said: ‘The legislative alterations we made to allow more audio and video hearings were temporary in accordance with the act that was passed. It seems to me that there is now an appetite to make at least some of these changes permanent.’However, the solemn nature of court proceedings should not be minimised or forgotten in the race to embrace technology, he added.last_img read more

Tunisian parliament signs anti-corruption strategy charter

first_img3rd anti-corruption congress opens in Tunisia Map of Tunisia.The Tunisian parliament on Friday signed the national anti-corruption and good governance strategy charter, reported the Tunis Afrique Presse (TAP) news agency.A joint media point was organized at the parliament on the occasion, attended by President of the National Anti-Corruption Authority (INLUCC) Chawki Tabib and the Parliament Speaker Rached Ghannouchi.Tabib called for hastening the election of INLUCC board members in accordance with Article 130 of the Tunisian Constitution.“The involvement of politicians in the fight against corruption cannot be reinforced without cooperation between parliament and government in this national strategy,” said Tabib.The INLUCC president asserted that 70 percent of the problems facing the north African country were related to lack of governance and spread of corruption beyond institutions’ ability.Related Mozambique hunts anti-corruption T-shirtscenter_img International Anti-Corruption Day 9 Decemberlast_img read more

Dialog Semiconductor Acquires Adesto Technologies for $500 Million

first_imgDialog Semiconductor, a leading provider of power management, charging, AC/DC power conversion, Wi-Fi and Bluetooth low energy technology, and Adesto Technologies Corporation, a leading provider of innovative custom integrated circuits (ICs) and embedded systems for the Industrial Internet of Things (IIoT) market, announced they have signed a definitive agreement for Dialog to acquire all outstanding shares of Adesto. The transaction is valued at $500 Million.Adesto brings to Dialog highly complementary products, world-class IP and comprehensive system expertise. The portfolios are a perfect match, especially as they look to provide even greater value for industrial customers who need reliable, efficient and secure solutions with embedded intelligence.Bringing Dialog and Adesto together creates a complementary product portfolio for servicing a broad customer base in growth segments of the industrial market and enables cross-selling.The combination of the companies will have many synergies:Will scale Dialog’s IIoT sector capabilities by combining industrial connectivity, smart metering and building automation solutions, and access to more than 5,000 customers, the majority of which are new for Dialog.Will Complement Adesto’s industrial wired connectivity portfolio with Dialog’s wireless portfolio (BLE, Wi-Fi) for smart building and industrial applications. Cloud-connectivity adds further differentiation to Dialog’s existing Industrial solutions.Enables full system solutions for wearables, hearables, and other IoT applications by combining Adesto’s low-power specialty memory products with Dialog’s BLE & Wi-Fi connectivity and True Wireless Stereo (TWS) Audio ICs.Unlocks future growth in the automotive market by qualifying Adesto’s specialty memory products by leveraging Dialog’s established automotive production and test flow. Additionally, these products address the emerging, fast-growing Artificial Intelligence (AI) segment.Adds engineering and design scale to expand Dialog’s existing custom IC business making Dialog one of the largest custom analog mixed-signal semiconductor providers.Customers should continue to engage with Dialog and Adesto through their current channels.last_img read more

SpaceX bill unanimously clears House Land and Resource Management Committee

first_imgSpecial to the PRESSLegislation which would further the SpaceX Boca Chica Beach commercial space launch project cleared the House Land and Resource Management Committee late Monday by a vote of 9-0.House Bill 2623 by State Rep. Rene Oliveira allows Cameron County to temporarily close an area of beach for launches and space flight activities with approval of the General Land Office.“It’s significant that we are moving quickly in the legislative process,” said Oliveira. “It’s important legislation that shows Texas is serious about promoting the space industry. It also demonstrates that Brownsville is committed to making the project happen.”Although SpaceX has not made a final decision to relocate to the area, Oliveira said he filed the bill to make certain the necessary legislative measures are in place to move the project forward. The bill now moves to the House Calendars Committee where it will be set for a date for full House approval.“The project has received amazing support at the local and state levels. We want to make the project happen here, but we are also making certain in the bill that the people of Cameron County have access to their beaches at peak times,” said Oliveira.The bill specifies that a county must have the approval of the state’s General Land Office before a launch may be made. The bill also prohibits the closure of a beach during the Saturday or Sunday preceding Memorial Day; Memorial Day; July 4; a Saturday after Memorial Day but before Labor Day; and, a Sunday after Memorial Day but before Labor Day.The proposed SpaceX project must still undergo federal scrutiny through the Federal Aviation Administration as well environmental impact studies. If the FAA does not approve SpaceX’s launch site, the beaches cannot be closed. Beaches may only be closed for a launch at an FAA approved site. If the FAA denies the site, the bill will have no effect. The FAA will address launch site environmental issues in its Environmental Impact Study. RelatedHearing set on SpaceX legislationSpecial to the PRESS A bill critical to the effort to attract SpaceX to the Brownsville area has been set for a hearing before a Texas House of Representatives’ committee. The bill will permit Cameron County and the GLO to temporarily close Boca Chica Beach for rocket launches, should SpaceX…March 28, 2013In “News”Officials revel in SpaceX groundbreaking; economic boon anticipated locallyBy JACOB LOPEZ Port Isabel-South Padre PRESS editor@portisabelsouthpadre.com BROWNSVILLE – Visitors to the Rio Grande Valley have long described the culture shock experienced at the border communities within as an out of this world experience. It’s a statement that can now be taken literally as Space Exploration Technologies (SpaceX) broke ground…September 25, 2014In “News”BEDC backs SpaceX at workshopBy AARIN HARTWELL Special to the PRESS Boca Chica Beach is among the top contingents of the first ever, commercial rocket launch site in the world only five miles south of South Padre. Brownsville Economic Development Council member Lizzy De La Garza presented on behalf of Space X Thursday, Add MediaMay…May 2, 2013In “News” Sharelast_img read more

Coronavirus: EPL matches to resume within weeks

first_imgThe Premier League is set to return in a matter of weeks, newsmen report.This follows plans to play matches behind closed doors, but for games to be shown for free on TV.Ever since the fixtures were suspended, there has been debate about how the 2019/2020 campaign should be concluded.All the top flight teams are believed to be desperate to finish the season no matter what it takes.With the UK still in lockdown, it is unlikely supporters will be allowed in stadiums before next year.It is also thought games could be streamed on terrestrial channels, amid worries that friends will gather at each others’ houses, if they do not have access to Sky Sports or BT Sport.The news comes after the Bundesliga announced they were prepared to resume their season again by May 9.Holland and Belgium are however among the nations who have decided to cancel their campaigns.last_img read more